Dissolution tests measure the rate of solution formation of various oral pharmaceutical dosage forms (such as suspensions, emulsions, solutions, caplets, capsules, and tablets), which are used to predict the absorption of these drugs.

Dissolution is a pharmacopoeial testing requirement for the vast majority of solid dosage forms. The dissolution test is used to develop and evaluate new drug formulations for quality control of the drug product and ensure that changes in the manufacturing process do not affect the drug product quality and performance. Dissolution testing is also useful for establishing in vitro/in vivo correlations.

How SIG can help

SIG laboratory provides dissolution testing services on a variety of dosage forms that are used orally. These testing services help you in the early development of new drug formulations and determine compliance with dissolution requirements stated in the pharmacopeia for preparations used orally.

Method of Analysis

The most commonly used methods are the basket (Type 1) and the paddle (Type 2), but many other methods are available (flowable cells, etc.). Further dissolution test analysis using the HPLC method.