Medical Devices
UV Lamp Products
Supporting Lab (Research Purpose)
Compounds Screening
Quality of Product for Indonesian Market

Oral & Dermal Acute Toxicity

Acute toxicity test is a study of the adverse effects that occur immediately after exposure to a single dose of the active ingredient or multiple doses within ± 24 hours. The difference between oral and dermal acute toxicity tests lies in the administration of exposure to the active ingredients by oral (mouth) and epidermis (skin). This test is carried out in vivo using rodents as the test subject.

Oral and dermal acute toxicity test is one of the technical requirements for the registration of pesticide products. This is regulated in the Regulation of the Minister of Agriculture.  In this regulation, acute toxicity is interpreted as Lethal Dose 50 (LD50), where the higher the LD50 value, the less toxic the active ingredient is.

This in vivo toxicity study is carried out to ensure product safety, considering that humans may be exposed to air, skin contact, or food. Therefore, the data from this test is required in the administration of pesticide products. The following limits are specified in the regulations.


Oral Acute Toxicity

LD50 (Rat)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg


Acute Skin Toxicity

LD50 (Rat)

(Solid) dosage: >100 mg/kg

(Liquid) dosage: >400 mg/kg


LD50 (Rabbit)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg


How SIG can help

The SIG laboratory can conduct toxicity tests on pesticide product matrices following the provisions stipulated in the regulations as an accredited toxicity testing agency/laboratory.


Method of Analysis

We use the standard method of toxicity test as determined by the Director-General on behalf of the Minister of Agriculture.

Library of Knowledge

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Bogor Laboratory & Main Office

Graha SIG:
Jl. Rasamala No. 20, Taman Yasmin, Bogor, Jawa Barat 16113.

Phone. +62(251) 7532348
Whatsapp. +62(821)11 516 516
Email. marketing-sig@saraswanti.com

Surabaya Laboratory

AMG Tower, 12th Floor, Jl. Dukuh Menanggal 1-A, Gayungan, Surabaya, Jawa Timur, 60234.

Phone: +6231 8253 1288

Jakarta Marketing Office

Ruko No.52B, Jl. Percetakan Negara, Rawasari, Cempaka Putih, Jakarta Pusat 10570.

Phone. +62(21) 21479292

Semarang Representative

Contact Person : Fajar Ery
Mobile : +62(0813) 91706805

Yogyakarta Representative

Contact Person : Zaimul Arifin
Mobile : +62(896) 48569422

Operational Hours

Monday to Friday
08.00 - 17.00 WIB.