Medical Devices

- Sterility Test

- Bioburden

UV Lamp Products
Supporting Lab (Research Purpose)
Compounds Screening
Quality of Product for Indonesian Market

- Acute Toxicity
Subchronic Toxicity
Chronic Toxicity
Systemic Toxicity
Rabbit Pyrogen Test
Eye irritation
Dermal Acute Irritation
Vaginal Mucous Irritation
LC 50 (Artemia)

Oral & Dermal Acute Toxicity

Acute toxicity test is a study of the adverse effects that occur immediately after exposure to a single dose of the active ingredient or multiple doses within ± 24 hours. The difference between oral and dermal acute toxicity tests lies in the administration of exposure to the active ingredients by oral (mouth) and epidermis (skin). This test is carried out in vivo using rodents as the test subject.

Oral and dermal acute toxicity test is one of the technical requirements for the registration of pesticide products. This is regulated in the Regulation of the Minister of Agriculture.  In this regulation, acute toxicity is interpreted as Lethal Dose 50 (LD50), where the higher the LD50 value, the less toxic the active ingredient is.

This in vivo toxicity study is carried out to ensure product safety, considering that humans may be exposed to air, skin contact, or food. Therefore, the data from this test is required in the administration of pesticide products. The following limits are specified in the regulations.


Oral Acute Toxicity

LD50 (Rat)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg


Acute Skin Toxicity

LD50 (Rat)

(Solid) dosage: >100 mg/kg

(Liquid) dosage: >400 mg/kg


LD50 (Rabbit)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg


How SIG can help

The SIG laboratory can conduct toxicity tests on pesticide product matrices following the provisions stipulated in the regulations as an accredited toxicity testing agency/laboratory.


Method of Analysis

We use the standard method of toxicity test as determined by the Director-General on behalf of the Minister of Agriculture.

Library of Knowledge

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Prove it Spicy by Scoville Heat Units Test!

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GMP+ International Certification

GMP+ International Certification

Along with SIG's determination to strengthen its existence as part of a global network and towards a safer world, we are proud to announce that SIG has successfully received its first GMP+ FSA International (Good Manufacturing Practice System, Feed Safety Assurance)...

SIG Laboratory

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WhatsApp. +62 82 111 516 516
Email. marketing-sig@saraswanti.com

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Phone. +62 31 8253 1288
WhatsApp. +62 818 885 165
Email. marketing@sigsurabaya.com


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Phone. +62 24 7640 3685
WhatsApp. +62 812 9000 5165
Email. cs.sigsmg@saraswanti.com


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