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Toxicity

Oral & Dermal Acute Toxicity

Acute toxicity test is a study of the adverse effects that occur immediately after exposure to a single dose of the active ingredient or multiple doses within ± 24 hours. The difference between oral and dermal acute toxicity tests lies in the administration of exposure to the active ingredients by oral (mouth) and epidermis (skin). This test is carried out in vivo using rodents as the test subject.

Oral and dermal acute toxicity test is one of the technical requirements for the registration of pesticide products. This is regulated in the Regulation of the Minister of Agriculture.  In this regulation, acute toxicity is interpreted as Lethal Dose 50 (LD50), where the higher the LD50 value, the less toxic the active ingredient is.

This in vivo toxicity study is carried out to ensure product safety, considering that humans may be exposed to air, skin contact, or food. Therefore, the data from this test is required in the administration of pesticide products. The following limits are specified in the regulations.

 

Oral Acute Toxicity

LD50 (Rat)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg

 

Acute Skin Toxicity

LD50 (Rat)

(Solid) dosage: >100 mg/kg

(Liquid) dosage: >400 mg/kg

 

LD50 (Rabbit)

(Solid) dosage: >50 mg/kg

(Liquid) dosage: >200 mg/kg

 

How SIG can help

The SIG laboratory can conduct toxicity tests on pesticide product matrices following the provisions stipulated in the regulations as an accredited toxicity testing agency/laboratory.

 

Method of Analysis

We use the standard method of toxicity test as determined by the Director-General on behalf of the Minister of Agriculture.

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