Description
Human existence is inextricably linked to the exposure of natural and chemical elements that may cause skin irritation. Irritation is the localized reaction of the skin to an irritant. The skin’s irritation reaction varies from erythema to oedema. Minor irritation may not be harmful to people, while severe irritation can cause discomfort and disrupt everyday living.The most crucial aspect is prevention, notably ensuring that materials exposed to humans do not have an irritating effect. An acute dermal irritation test can be used to evaluate a compound’s irritating potential.

Acute dermal irritation is a test performed on animals to detect the presence of an irritating effect on the skin as well as to analyze and evaluate the characteristics of a substance when it comes to contact with the skin. Traditional medicines, supplements, cosmetics, pesticides, and medical equipment that come into direct contact with human skin are all candidates for acute skin irritation testing. This test is carried out in accordance with the appropriate rules and regulations, which are designed to aid in the process of registering new domestic goods.

How can SIG help?
As an approved toxicity testing laboratory, SIG can undertake acute dermal irritation tests on the matrix of pharmaceutical goods, traditional medicines, health supplements, cosmetics, processed foods, pesticides, and medical devices according to each applicable guidance.

Method of Analysis
We conduct the tests in accordance with the toxicity guidelines provided by the Indonesian government, which include:

1. BPOM Regulation (Drugs, traditional medicine, supplement, cosmetics, and food processed)
2. Toxicity guidance by Directorate of Fertilizer and Pesticides (Pesticides)
3. ISO 10993 (Medical Devices)