Residual solvent was a volatile organic compound that remained in finished products which have the potential to risk the health and do not have a beneficial function. These compounds are used as auxiliary material, generally as an extraction solvent, in the production process. In Indonesia, BPOM regulates residual solvent as an auxiliary material for the extracting solvent in BPOM Regulation No. 20/2020. In addition, a residual solvent may also come from cross-contamination or migration from product packaging.

 

How SIG can help

SIG Laboratory performs residual solvent analysis on foods and pharmaceutical products matrices based on United States Pharmacopeia official method.

The types of solvent residues that can be tested in the SIG laboratory are:

  • Acetone
  • Acetonitrile
  • Methyl Alcohol
  • Ethyl Alcohol
  • Benzene
  • Ethyl Benzene
  • Chloroform
  • Cyclohexane
  • Dichloromethane
  • Ethyl Acetate
  • n-Hexane
  • Iso-Propanol
  • n-Butanol
  • Tetrahydrofuran
  • Toluene
  • Triethylamine
  • Xylenes

 

Method of Analysis

Autosampler HeadSpace GC is the most likely technique to be used in solvent residues analysis.

Library of Knowledge

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