Get to know LC MS QToF Technology
LC-MS QToF,also known as one of-igh Resolution Mass Spectrometry (HRMS) instrumentation technology, provides accurate mass measurement results. Thanks to this capability, LC-MS QToF can offermore comprehensive information regarding the exact molecular mass, elemental composition, and detailed molecular structure of a particular compound.
LC MS QToF Principle
The analytes/compounds in the prepared samples are first separated by liquid chromatography (LC) using a chromatography separation column and then passed into a Quadrupole Time-of-Flight (QToF) mass spectrometer system, which combines the ion selection properties of a quadrupole (Q) with Time-of-Flight (ToF) mass analysis. This system offers both mass resolution and high accuracy in one system. The mass to charge ratio (m/z) of an ion is determined by measuring the flight time of an ion accelerated by an electric field of known strength over a known distance. Heavier ions move slower than lighter ions.
What LCMS QToF Can Do
- Able to distinguish compounds more specifically
- Can be used for qualitative (screening) and quantitative analysis, including analysis of targeted, suspected and non-targeted compounds.
- The reading results can be in the form of full scan spectra, which can be stored and used in further studies, making it possible to utilize them in formulations involving elucidation of the structure of an unknown or suspected compound.
Future of LCMS QToF
Now and in the future, QToF LCMS technology is predicted to be able to be used for various research needs, including:
- Screening for active substances from natural ingredients in herbal commodities
- Screening for pesticide residue contamination
- Analysis of related compounds and impurities, for example, detecting product adulteration or counterfeiting
- Support in omics study disciplines such as metabolomics, lipidomics, and proteomics
- Support in determining product halal status (Halal Study)
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